C2sc20239e 2234..2239
نویسندگان
چکیده
Several Zn b-diiminate reagents were developed and used to mediate regioselective O-acylation reactions of therapeutic agents with anhydrides. Various prodrugs were obtained in excellent yield and high regioselectivity, including derivatives of rapamycin and paclitaxel. Furthermore, the application of regioselective acylation was extended to one-pot reactions between therapeutics and carboxylic acids with various pendant functional groups. This rapid functionalization strategy will find application in either prodrug synthesis or bioconjugation for drug delivery.
منابع مشابه
Cerebral Artery Occlusion : Adverse Effects of Hypothalamic Damage and Strategies for Neuroprotective Effects of MK-801 in Different Rat Stroke Models for Permanent Middle
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